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Clenbutaplex

Clenbutaplex 300x300 ClenbutaplexGENERAL INFORMATION:

Substance: Clenbuterol Hydrochlorideclenbutaplex
Manufactured by: Axiolabs
Packaging: 50 tabs, each tab 0.04mg
Half Life: 60 – 72 hours
Average Dose: 100-140mcg/day(M) 80-100mcg/day(F)
Acne: No
Water Retention: No
High Blood Pressure: Sometimes
Liver Toxic: Unknown
Aromatization: None
Strong Thermogenic

Two times stronger than conventional spiropent and superior to hubei, Clenbutaplex is Medically used throughout many parts of the world as a broncodilator for the treatment of asthma, is a recent and popular addition to the realm of athletics. It is a beta-2 agonist, with properties somewhat similar to adrenaline. Clenbuterol acts as a CNS stimulant and users quite commonly report side effects such as shaky hands, insomnia, sweating, increased blood pressure and nausea. These side effects generally subside quickly once the user becomes accustomed to the drug. Athletes find clenbutaplex attractive for it”s pronounced thermogenic effects as well as mild anabolic properties. Dosage regimes will vary depending on the desired effect. Clenbutaplex comes in 40mcg tablets. Clenbutaplex users will usually tailor there dosage individually, depending on results and side effects, but somewhere in the range of 2-8 tablets per day is most common. For fat loss, Clenbutaplex seems to stay effective for 3-6 weeks, then it”s thermogenic properties seem to subside. This is noticed when the body temperature drops back to normal.

Clenbutaplex (Clenbuterol Hydrochloride)Clenbutaplex (Clenbuterol) – “A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.” Medical Dictionary

Clenbutaplex (Clenbuterol) is classified as a beta-2 adrenergic agonist. Clenbuterol is a bronchiodilator. This drug is banned by the FDA although it is used outside the US by asthma patients. The reason although it is fairly anabolic, and it promotes the burning of fatty acids through brown fat burning. Clenbuterol is a little scary because of some other side effects including the following: tremors, sweating, sleeplessness, rapid heartbeat, etc. These side effects vary in people. Some people aren`t affected at all.

HOW DOES IT WORK
“Clenbutaplex (Clenbuterol) works the same way as ephedrine. However, unlike ephedrine, which is out of the body in a few hours, clenbuterol lasts for days. So you are on it 24 hours a day. No one chooses to be on ephedrine 24 hours per day, because it interferes with sleep, and so clenbuterol is more effective” says Bill Roberts (Bill Roberts holds a bachelor’s degree in Microbiology and Cell Science, and a doctoral degree (Ph.D.) in Medicinal Chemistry)

Clenbutaplex (Clenbuterol) does work effectively as a fat burner though. It does this by slight increases in the body temperature. With each degree that the temperature in your body is raised from the use of clenbuterol, you will burn up approximately an extra 5% of maintenance calories. This makes it effective as a fat burner. Your body will fight this by cutting down on the amount of active thyroid in the body as well as through beta receptor down regulation which explains why you only have a limited effective period to take clenbuterol.

Clenbutaplex and Fat Loss

Clenbutaplex (Clenbuterol) is a very effective repartitioning agent, and this is what it´s most often used for in athletic circles. It will increase your ratio of Fat Free Mass (FFM) to Fat Mass, by decreasing your Fat and possibly increasing your FFM (3). Lets quantify that a bit:

In one study, horses given a semi-reasonable dose of clen (slightly over 1mcg/lb x2 a day) and exercised for 20mins, 3x a week ( I suppose they were Mentzer disciples) had significant decreases in %fat (-17.6%) and fat mass (-19.5%) at week 2, which was similar to Clen given to horses who didn´t exercise; in contrast, the exercised group had a different FFM response, which significantly increased (+4.4%) at week 6 (3). Week 6! Here´s a chart illustrating the changes in % of Body Fat experienced in the various test groups, followed by a chart showing the increase in Fat Free Mass experienced by the same groups.

There´s still no doubt about it, in my mind Clen will help you lose fat and gain muscle.

So Let´s re-examine that first point I made: Clen vs. clen+ exercise produce roughly the same results for the first 2 weeks! This tells me that the 2 weeks on and 2 weeks off schedule for clen dosing is far from optimal, and if you want the quasi-anabolic effect from the clen, it´ll take more than 2weeks on (6 weeks apparently). In addition, since clen alone is similar to clen+ exercise for those first 2 weeks…why would you ever use a 2on/2off protocol? Keep in mind that animal responses to beta-agonist/antagonists differ a bit from ours but I´m sure that you get the idea that 2on/2off is not a great dosing protocol. If I were using clen, I´d be using it for 6-12 weeks at a time, if I expected to get maximum results from it, but certainly, the most dramatic effects on fat loss appear to be in weeks 1-2. The reasons for the further increase in FFM around week 6 despite no changes in %fat or fat mass is not easily explained… It might be that clenbuterol can increases FFM through another nonreceptor-mediated pathway, which would be very good for us, since the anabolic effects would also be applicable in humans, despite the fact that animals often respond more dramatically to beta-agonist/antagonists, due to receptor properties.. However, clenbuterol is highly lipophylic and can also enter muscle tissue (12), so that could indicate a possible mechanism of work. Maybe that would explain the significant increase in FFM of 13 kg in at 8 wks in the study? Certainly, muscle protein synthesis (MPS) must be a part of it, since clen will increase MPS in your body (17)& But it has even been speculated that the growth-promoting effect of clenbuterol may be specific to muscle and that the drug may act in a not-yet-understood manner which circumvents (!) the physiological mechanisms responsible for the control of muscle growth (13). This may mean that clenbuterol can help blast you past “sticking points” in your training by circumventing the usual mechanisms by which anabolism is experienced! It is of note that both muscle composition and fiber size has been shown to increase with administration of clen (14).

In any case, Clearly the results you want to reproduce for yourself are those to be gained by clen + exercise, for 6 weeks or more. This type of dramatic anabolic effect hasn´t been confirmed in human studies (8), but the anabolic effects of clen in animal (specifically equine and rodent) studies are clearly quite astounding.

Now that I told you how great clen is; I´ll tell you how to take it

Clen has a biphastic elimination, which means that it is technically reduced in your body in 2 different stages. This isn´t particularly important, as a recent study has shown that for most intents and purposes, clen concentrations in the body decline with a ½ life (approximately) equivalent to 7-9.2hours and again up to as much as 35 hours later(4)(5). If you´re really interested, though, clen technically declines biphastically at 10 and then 36 hours. But really, in our little world, where we use ½ life to tell us when to take our next dose, who the hell is going to take clen, then a dose 10 hours later, then a dose 36 hours later? We´ll stick with the earlier 7-9 hour ½ life for dosing purposes, and take our clen every 3.5-4.5 hours that we´re awake, stopping early enough to still be able to get to bed. Clen can, in some people, cause insomnia (and as with all stimulants, can cause anxiety in some). Recently, it´s become popular to take a whopping dose of clen in the morning, and that´s it for the day. There´s nothing wrong with this, I guess, but I´d rather not go through that kind of roller-coaster of sweating and shaking until it wore off.

SIDE EFFECTS
The possible side effects of clenbuterol include those of other CNS(central nervous system) stimulants, and include such occurrences as shaky hands, insomnia, sweating, increased blood pressure and nausea. These side effects will generally subside after a week or so of use however, once the user becomes accustomed to the drug. Another thing people should be aware of is the inherent liver toxicity associated with clenbuterol use. When stacking with oral 17-alpha-alkylated steroids, accutane, anti-biotics or other hepatoxic elements, one should have his liver values checked by a licensed physician at regular points in time to avoid all problems. If you not a yellow discoloration of the skin cease use immediately and contact your doctor.

STACKING CLENBUTEROL WITH OTHER SUBSTANCES
Caution is advised when employing the use of Clenbuterol in conjunction with other adrenoceptor agonists as side effects are likely to be cumulative. It is for this reason that it is generally not recommended to use ephedrine/ephedra (or ma huang) or the ECA stack (ephedrine-caffeine-aspirin) whilst using clenbuterol. In view of the above side effects, it is obvious to assume that anyone with cardiac issues and/or hypertension should not use a stimulant such as Clenbuterol and caution must be observed by those already using similar compounds in the treatment of existing medical conditions. In addition, there is very little conclusive knowledge of the cardiac effects of supra-physiological dosages in humans.

USAGE
It is well known that Clenbuterol use results in rapid down-regulation of beta 2 receptors. This is due to the powerful stimulatory effect of the drug. It is therefore pointless to use clen for long periods without a break. Some believe that a two day on, two day off dosing schedule will allow adequate potential for receptor up-regulation. However, I doubt this to be the case due to the relatively long half life of clen, resulting in continued stimulation even throughout the ‘off’ days. A much better regime would be a two week on, two week off cycle. Maximum plasma levels are reached around 2-3 hours after oral administration, and terminal half life at 34 hours (Zimmer, 1976).

It is recommended to start by taking one 20mcg tablet on the first day and then increase the dosage on the subsequent days by one tablet until the needed dosage is reached. For fat loss, clenbuterol seems to stay effective for 3-6 weeks, then it’s thermogenic properties seem to subside.

There are many theories on what is the best schedule: a two week on, two week off, or one week on, one week off. MusclesProd.Com suggests you to find out what works best for you through experiencing.

Before starting new cycle you must wait at least for two months.

You also must be very well hydrated.

WILL CLENBUTAPLEX HELP ME BURN FAT?
DIET AND CARDIO are MOST IMPORTANT in this process! If one sits all the day in front of TV eating all he wants, effectiveness of Clenbuterol will be GREATLY reduced!
So, training, diet, cardio and supplements should be “taken” together. Do not try to use short cuts because they do not work!

References:
Zimmer (1976). Single and multiple applications and metabolite pattern of clenbuterol in man (author’s transl). Arzneimittelforschung 26(7a):1446-50. Also were used different articles from trusted sources.

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